8858/3 Dedifferentiated liposarcoma


Definitions

Connective, subcutaneous and other soft tissues
ICD-O-3 topography code: C49
ICD10: C49
           

Dedifferentiated liposarcoma is a malignant, adipocytic soft tissue tumour of adults, presenting as large multinodular mass, preferentially in the retroperitoneum, less frequently in the extremities and the spermatic cord. It occurs de novo (>90% of cases) or through progression from atypical lipomatous tumour/well differentiated liposarcoma (ALT/WDL) and is histopathologically characterized by features of transition from ALT/WDL to non-lipogenic sarcoma. The genetic profile includes supernumerary ring and giant marker chromosomes and frequent 12q13-21 amplification 1
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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