8074/3 Squamous cell carcinoma, spindle cell


Synonyms

Epidermoid carcinoma, spindle cell
Squamous cell carcinoma, sarcomatoid

Definitions

Esophagus
ICD-O-3 topography code: C15
ICD10: C15
           

A poorly differentiated squamous cell carcinoma characterized by a variable presence of malignant cells with spindle cell features. 1
Click to access Pubmed
Lauwers GY, Grant LD, Scott GV, Carr NJ, Sobin LH (1998)
Spindle cell squamous carcinoma of the esophagus: analysis of ploidy and tumor proliferative activity in a series of 13 cases.
Hum Pathol 29: 863-8



2
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



. Grossly, it is polypoid, usually involving the middle and lower third of the oesophagus. Microscopically, it is biphasic with epithelial and spindle cells.



Lip, Oral Cavity and Oropharynx
ICD-O-3 topography code: C00-C06, C09-C10, C14
ICD10: C00-C06, C09-C10, C14
           

A poorly differentiated squamous cell carcinoma characterized by the presence of malignant cells with spindle cell features.



Hypopharynx, Larynx and Trachea
ICD-O-3 topography code: C13, C32, C33
ICD10: C13, C32, C33
           

A poorly differentiated squamous cell carcinoma characterized by the presence of malignant cells with spindle cell features.



Skin
ICD-O-3 topography code: C44
ICD10: C44
           

Spindle cell squamous cell carcinoma is a poorly differentiated variant of squamous cell carcinoma characterized by the presence of malignant cells with spindle cell features. The tumour usually arises in sun-damaged or irradiated skin and presents as a plaque or nodule. The clinical course can be aggressive
3
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



.



Penis
ICD-O-3 topography code: C60
ICD10: C60
           

A poorly differentiated squamous cell carcinoma characterized by the presence of malignant cells with spindle cell features.



Nasal cavity and Sinuses
ICD-O-3 topography code: C30-C31
ICD10: C30-C31
           

A poorly differentiated squamous cell carcinoma characterized by the presence of malignant cells with spindle cell features.