8850/0 Lipoma, NOS


Definitions

Tumours of the central nervous system
ICD-O-3 topography code: C70, C71 and C72

Lipoma is the most common soft tissue tumour and composed of mature white adipocytes 1
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



. It typically manifests in adults and surgical resection is usually curative.

Intracranial lipomas are believed to be congenital malformations rather than true neoplasms, resulting from an abnormal differentiation of the meninx primitiva, the undifferentiated mesenchyme
2
Click to access Pubmed
Kakita A, Inenaga C, Kameyama S, Masuda H, Ueno T, Honma J, Shimohata M, Takahashi H (2005)
Cerebral lipoma and the underlying cortex of the temporal lobe: pathological features associated with the malformation.
Acta Neuropathol (Berl) 109: 339-45



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Breast
ICD-O-3 topography code: C50

A benign tumour composed of mature adipocytes without atypia.





Connective, subcutaneous and other soft tissues
ICD-O-3 topography code: C49

Lipoma is the most common soft tissue tumour in adults. It is a benign neoplasm composed of mature white adipocytes. Tumours can originate from subcutaneous tissue (superficial lipomas), from deep soft tissue (deep lipomas), or from the surface of bone (parosteal lipomas). Tumours are generally well circumscribed; as a rule, superficial lipomas are smaller (<5cm) than the deep seated ones (>5cm). Occasionally, areas of bone formation (osteolipoma), cartilage (chondrolipoma), abundant fibrous tissue (fibrolipoma), or extensive myxoid change (myxolipoma) can be observed within the tumours
7
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Lipoma manisfests most commonly in adults 40 to 60 years of age and is more frequent in obese individuals. Surgical resection is usually curative. Infiltrating intramuscular lipomas show a higher local recurrence rate; total removal of the involved muscle or a compartmental resection is suggested in these cases
8
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Colon and rectum
ICD-O-3 topography code: C18-C20

Lipoma is the most common soft tissue tumour and composed of mature white adipocytes
9
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



. It typically manifests in adults and surgical resection is usually curative.

Lipoma of the colon and rectum
Submucosal lipomas occur especially in the colon, usually detected in older adults as an incidental finding. Larger tumours may cause obstruction, ulcerate and undergo necrosis resulting in gastrointestinal haemorrage. Histologically, there is mature adipose tissue without significant atypia. Thick-walled dilated blood vessels are often present in these lipomas, although they differ from peripheral angiolipomas
10
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Hypopharynx, Larynx and Trachea
ICD-O-3 topography code: C13, C32, C33

Lipoma is the most common soft tissue tumour and composed of mature white adipocytes
11
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



. It typically manifests in adults and surgical resection is usually curative.



Small intestine
ICD-O-3 topography code: C17

Lipoma is the most common soft tissue tumour and composed of mature white adipocytes
12
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



. It typically manifests in adults and surgical resection is usually curative.



Thymus
ICD-O-3 topography code: C37

Lipoma is the most common soft tissue tumour and composed of mature white adipocytes
13
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



. It typically manifests in adults and surgical resection is usually curative.



Bone
ICD-O-3 topography code: C40-C41

Lipoma is the most common soft tissue tumour and composed of mature white adipocytes
14
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



. It typically manifests in adults and surgical resection is usually curative.



Pancreas
ICD-O-3 topography code: C25

Lipoma is the most common soft tissue tumour and composed of mature white adipocytes
15
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



. It typically manifests in adults and surgical resection is usually curative.

Lipomas of the pancreas have been reported, and should be distinguished from non-neoplastic fat accumulation. These lesions are particularly problematic because their low attenuation on computed tomography (CT) imaging can mimic a pancreatic cancer
16
Click to access Pubmed
Kawamoto S, Siegelman SS, Bluemke DA, Hruban RH, Fishman EK (2009)
Focal fatty infiltration in the head of the pancreas: evaluation with multidetector computed tomography with multiplanar reformation imaging.
J Comput Assist Tomogr 33: 90-5



. In most cases, magnetic resonance imaging (MRI) can detect the lipomatous nature of these lesions17
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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