8815/0 Solitary fibrous tumor


Synonyms

Localized fibrous tumor

Definitions

Tumours of the central nervous system
ICD-O-3 topography code: C70, C71 and C72

A relatively rare, spindle-cell, fibroblastic tumour that typically shows a prominent haemangiopericytoma-like vascular pattern. It is histopathologically characterized by the presence of round to spindle-shaped cells, hyalinized stroma formation, thin-walled branching blood vessels, and thin bands of collagen.



Thyroid gland
ICD-O-3 topography code: C73

A relatively rare, spindle-cell, fibroblastic tumour that histologically shows a prominent haemangiopericytoma-like vascular pattern. It is histopathologically characterized by the presence of round to spindle-shaped cells, hyalinized stroma formation, thin-walled branching blood vessels, and thin bands of collagen1
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



.

Solitary fibrous tumor (SFT) of the thyroid gland is an uncommon neoplasm mainly observed in middle-aged adults, with a slight predominance of females
2
 
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



. Recurrence or distant metastasis have not been reported but there are too few documented cases to allow a definitive conclusion 3
Click to access Pubmed
Cameselle-Teijeiro J, Varela-Duran J, Fonseca E, Villanueva JP, Sobrinho-Simoes M (1994)
Solitary fibrous tumor of the thyroid.
Am J Clin Pathol 101: 535-8



4
Click to access Pubmed
Deshmukh NS, Mangham DC, Warfield AT, Watkinson JC (2001)
Solitary fibrous tumour of the thyroid gland.
J Laryngol Otol 115: 940-2



5
Click to access Pubmed
Rodriguez I, Ayala E, Caballero C, De Miguel C, Matias-Guiu X, Cubilla AL, Rosai J (2001)
Solitary fibrous tumor of the thyroid gland: report of seven cases.
Am J Surg Pathol 25: 1424-8



.



Liver and intrahepatic bile ducts
ICD-O-3 topography code: C22

A relatively rare, spindle-cell, fibroblastic tumour that typically shows a prominent haemangiopericytoma-like vascular pattern. It is histopathologically characterized by the presence of round to spindle-shaped cells, hyalinized stroma formation, thin-walled branching blood vessels, and thin bands of collagen.

Hepatic solitary fibrous tumour (previously also known as localized fibrous tumour and localized fibrous mesothelioma) originates from the submesothelial tissue of the liver. It occurs in patients aged 16?84 years (mean, 55 years)
6
Click to access Pubmed
Moran CA, Ishak KG, Goodman ZD (1998)
Solitary fibrous tumor of the liver: a clinicopathologic and immunohistochemical study of nine cases.
Ann Diagn Pathol 2: 19-24



7
Click to access Pubmed
Perini MV, Herman P, D'Albuquerque LA, Saad WA (2008)
Solitary fibrous tumor of the liver: report of a rare case and review of the literature.
Int J Surg 6: 396-9



and with a female-to-male predominance of 2 : 1. Clinical presentation includes mild abdominal discomfort and presence of a solid abdominal mass. Some cases are associated with hypoglycaemia caused by the production of an insulin-like growth factor 8
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.



Thymus
ICD-O-3 topography code: C37

A relatively rare, spindle-cell, fibroblastic tumour that typically shows a prominent haemangiopericytoma-like vascular pattern. It is histopathologically characterized by the presence of round to spindle-shaped cells, hyalinized stroma formation, thin-walled branching blood vessels, and thin bands of collagen.



Kidney
ICD-O-3 topography code: C64

A relatively rare, spindle-cell, fibroblastic tumour that typically shows a prominent haemangiopericytoma-like vascular pattern. It is histopathologically characterized by the presence of round to spindle-shaped cells, hyalinized stroma formation, thin-walled branching blood vessels, and thin bands of collagen
9
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



.

Solitary fibrous tumours of the kidney arise in the renal parenchyma and present as large, well-circumscribed masses. They may clinically be confused with renal cell carcinoma or a sarcoma
10
 
Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



.



Prostate gland
ICD-O-3 topography code: C61

A relatively rare, spindle-cell, fibroblastic tumour that typically shows a prominent haemangiopericytoma-like vascular pattern. It is histopathologically characterized by the presence of round to spindle-shaped cells, hyalinized stroma formation, thin-walled branching blood vessels, and thin bands of collagen.